An in-vivo study of MIM 316L bone fracture fixation plates

December 2, 2015

MIM is regarded as offering a revolutionary new class of medical implants for orthopaedics. Dr Mohd Afian Omar and his colleagues at the Advanced Materials Research Center (AMREC), SIRIM Berhad and Faculty of Medicine, International Islamic University of Malaysia (IIUM), have been investigating the in-vivo study of MIM 316L stainless steel fracture fixation plates for bone fracture repair.

An in-vivo study of MIM 316L bone fracture fixation plates - Fig-1

Fig. 1 X-Ray assessment of implantation of MIM plate (lateral view) at different weeks

In order to evaluate the bone tissue reaction to the 316L stainless steel plates manufactured by MIM for in bone plate fixation, an experiment with rabbits was performed by a group of orthopaedic surgeons and researchers from the Department of Orthopaedic and Traumatology, IIUM and Biomedical Materials Programme, AMREC. This is the continuation of successful collaboration research between SIRIM Berhad and IIUM for the fabrication of injection moulded fracture fixation plates over the last two years. In this study, the animal experiments on fracture fixation were investigated by radiographic assessment and gross inspection via hard tissue processing, since each sample comprises bone and metal plate. A total of 40 rabbits were used for this study. Experimental fractures were made in rabbit tibia and fixed with either a MIM plate or a conventional mini plate which served as a control.

In X-Ray assessment at the three week interval post-surgery, bridging callus is present in both groups (Fig. 1). The bone union was obtained and the fracture line invisible at week six. Early intramedullary canal is taking place at week nine and at week twelve, continuity of bone cortex is present. The new bone is fully remodelled and the plate in-situ in both groups at week 26. For gross inspection, at week three of post implantation (Fig. 2a) no obvious changes occurred, the transverse fracture at mid shaft tibia was noted with implant in-situ. Fracture callus was present but was immature and soft. The new bone had covered the plate and strongly bonded to the surface of the plate at week 26 (Fig. 2b) and the plate is straight and parallel to the operated bone.

An in-vivo study of MIM 316L bone fracture fixation plates - Fig-2

Fig. 2 Implantation of MIM plates at different weeks: a) MIM plate at week 3, b) MIM plate at week 26

Callus formation was seen along the implantation site in MIM plates. The fracture was healed after application of MIM plate without any soft tissue reaction. Thus, results of the present study show the return of the bone to normal anatomy is achieved with the presence of bone remodeling at week 12. This showed that the MIM plate is able to sustain its function from day one of fixation until remodeling take place at week 26.

Data from radiographic analysis and gross observation evidenced that MIM plates are compatible and able to induce new bone formation. These results revealed that the MIM plate shown has the comparable function capabilities as the conventional plate to hold the fracture fragments and promote immobilisation for the fracture healing process. Therefore, the MIM plates can be used as an alternative internal fixator for fracture management in orthopaedics.

Email: [email protected]   |


In the latest issue of PIM International…

Download PDF

Extensive MIM, CIM industry and sinter-based AM industry news, plus the following exclusive deep-dive articles and reports:

  • Calling all product designers: Discover what Metal Injection Moulding could do for you through these award-winning parts
  • Binder Jetting of a dual-phase steel: Process insight and optimisation using the Master Sintering Curve
  • The rise of filament-based metal AM: New materials and machines present opportunities for MIM producers
  • Sinter-based Additive Manufacturing at the 20th Plansee Seminar on Refractory Metals and Hard Materials
  • Ceramitec 2022: Opportunities abound for producers of technical ceramics by CIM and AM

The latest news from the MIM, CIM and sinter-based AM industries

Don't miss any new issue of PIM International, and stay up to date with the latest industry news. Sign up to our fortnightly newsletter.

Sign up

News from the industry…

    Discover our magazine archive…

    The free-to-access PIM International magazine archive offers unparalleled insight into the world of MIM, CIM and sinter-based AM from a commercial and technological perspective through:

    • Reports on visits to leading part manufacturers and industry suppliers
    • Articles on technology and application trends
    • Information on materials developments
    • Reviews of key technical presentations from the international conference circuit
    • International industry news

    All past issues are available to download as free PDFs or view in your browser.


    Browse the archive


    Looking for suppliers of materials, production equipment and finished MIM, CIM or sinter-based AM parts?

    Discover suppliers of these and more in our advertisers’ index and buyer’s guide, available in the back of PIM International.

    • Metal powders
    • MIM, CIM & AM parts producers
    • Binders & feedstocks
    • Feedstock mixers
    • Furnaces & furnace supplies
    • Atmospheres & gas generation
    • HIP systems & services
    • Injection moulding machines
    • AM technology
    • Debinding systems
    Download PDF
    Share via
    Copy link
    Powered by Social Snap